Infection and Immunity IIIA

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  • UniversityUniversity of Adelaide
  • AreaScience and technology
  • CourseInfection and Immunity IIIA
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81%Verified Grade
  • Authoreiffel
  • Created2014
  • Pages34
  • Approved9 August 2014

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About these notes

Notes on the following areas:

Lecture 1: Introduction to pathogens 4
Emerging infectious diseases 4
Drivers of EID events 4
Strategies 4
Lecture 2: Bacterial pathogens – colonization of host surfaces 5
Colonisation 5
Pili 5
Pap Pili 5
Lecture 3: Bacterial pathogens – invasion of host cells 6
Type IV pili 6
Biofilm formation 6
Invasion Strategies 6
Capsules and complement 6
LPS and complement 6
Lecture 4: Bacterial pathogens – strategies to avoid host defenses 7
Cell wall proteins and complement 7
Iron availability 7
Proteases and inactivation of immunoglobulins 7
Avoidance of killing by phagocytosis 7
Resistance to defensins 7
Resistance to oxygen radicals 7
Resistance to neutrophil NETS 7
Avoidance 7
Lecture 5: Intracellular bacterial pathogens I – Shigella 8
Shigellosis 8
Virulence Genes 8
Lecture 6: Intracellular pathogens II – Salmonella 9
Typhoid Fever 9
Salmonella Virulence Factors 9
Invasion of epithelial cells 9
PhoPQ 9
Lecture 7: Subversion of host cell systems by IBPs I 10
Actin 10
Actin polymerisation and cell invasion 10
Intracellular Survival 10
Lecture 8: Subversion of host cell systems by IBPs II 11
Cell Death mechanisms 11
Bacterial strategies 11
Shigella flexneri and non-myeloid cells 11
Shigella flexneri and myeloid cells 11
Lecture 9: Cell surface polysaccharides of bacterial pathogens 12
LPS function 12
LPS synthesis 12
Morona’s model of model chain length determination 12
Lecture 11-13: Gene regulation and stress response I-III 13
Transcription 13
Lecture 14: Antibiotics and resistance 14
Resistance Mechanisms 14
Spreading resistance 14
Lecture 15: Antibiotics for the 21st century 15
Finding new antibiotics 15
Reducing unnecessary antibiotic use 15
Lecture 16: Vaccines for bacterial pathogens I 16
Killed Vaccines 16
Cholera Vaccine 16
Pertussis Vaccine 16
Conjugate vaccines 16
Lecture 17: Vaccines for bacterial pathogens II 17
Live Vaccines 17
Salmonella 17
Protein glycan coupling technology 17
Lecture 18: Antigenic and phase variation I 18
Antigenic Variation 18
Phase Variation 18
Lecture 19: Antigenic and phase variation II 19
Phase Variation cont. 19
Cross Regulation 19
Lecture 20: Bacteriophage and virulence 20
Pathogenicity islands 20
Secretion systems 20
Bacteriocins 20
Vibrio cholera and Vibriophage 20
Lecture 21: Stress responses I 21
ROS and RNS 21
Protective Enzymes 21
Lecture 22: Stress responses II 22
Transcription factors 22
Lecture 23: Stress Response – Neisseria gonorrheae 23
Neisseria gonorrheae 23
Pathogenesis 23
Virulence factors 23
Lecture 24: Stress Response – Neisseria meningitidis 24
Pathogenesis 24
Virulence factors 24
Lecture 25: Stress Response – Mycobacterium tuberculosis 25
Pathogenesis and virulence factors 25
Lecture 26: Stress Response – Staphylococcus aureus 26
Pathogensis 26
Virulence factors 26
Lecture 27: Streptococcus pneumoniae I 27
Virulence factors 27
Lecture 28: Streptococcus pneumoniae II 28
Virulence factors cont. 28
Pathogensis 28
Vaccination 28
Lecture 29: Bacterial gene expression during infection I 29
Pathogenesis 29
Treatments 29
Screening in vivo induced genes 29
Lecture 30: Bacterial gene expression during infection II 29
Screening in vivo induced genes cont. 29
Lecture 31: Pseudomonas aeruginosa and virulence 30
Biofilms 30
Cystic Fibrosis 30
Virulence Factors 30
Lecture 32: Membrane proteins and their role in virulence 31
Membrane proteins 31
Drug resistance 31
Lecture 33: Listeria monocytogenes 32
Invasion 32
Virulence Factors 32
Lecture 34: Bacterial infections – risk assessment I 33
Framework 33
Salmonella enteritiditis 33
Lecture 35: Bacterial infections – risk assessment II 34
Hazard Analysis and Critical Control Point Analysis (HACCP) 34
Oyster Microbiology Risks and Intervention 34
Vibrio parahaemolyticus and vulnificus 34
Risk Analysis 34

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